Ophthalmic Imaging for Eye and Brain Disease

Theme 4

Development of cutting-edge imaging devices to diagnose eye diseases and identify ocular biomarkers to diagnose brain diseases.

Ophthalmic imaging of the retina is in its “golden era”. Retinal tissues have a myriad of textural/contrast features that can be visualized and captured under different lighting and contrast settings. Today, in vivo imaging of the retina in animal models can identify dying retinal ganglion cells in glaucoma or in Alzheimer’s. Engineering and animal model experts will work side- by-side to identify relevant textural and contrast signatures that represent eye and/or brain diseases.

Chair

Myeong Jin Ju

Principal Investigators

Lauren Ayton, Hye Jin Chung, Cheryl Gregory-Evans, Myeong Jin Ju, Geoffrey Law, Blair Leavitt, Da Ma, Zaid Mammo, Joanne Matsubara, Orson Moritz, Ipek Oruç, Jacqueline Quandt, Shuo Tang

Publications and Articles
Publication Journal or Publisher Publication Date
Segmentation-guided domain adaptation and data harmonization of multi-device retinal optical coherence tomography using cycle-consistent generative adversarial networks Computers in Biology and Medicine
Safety, tolerability, and effectiveness of the sodium-glucose cotransporter 2 inhibitor (SGLT2i) dapagliflozin in combination with standard chemotherapy for patients with advanced, inoperable pancreatic adenocarcinoma: a phase 1b observational study Cancer & Metabolism
Progressive alterations in white matter microstructure across the timecourse of Huntington's disease Brain and Behavior
Peripapillary choroidal cavitation as a feature of pathological myopia BMJ Case Reports
Genome Editing of Pik3cd Impedes Abnormal Retinal Angiogenesis Human Gene Therapy
Predicting time-to-conversion for dementia of Alzheimer's type using multi-modal deep survival analysis Neurobiology of Aging
SPECHT: Self-tuning Plausibility based object detection Enables quantification of Conflict in Heterogeneous multi-scale microscopy PLoS One
Cerebrospinal fluid biomarkers for assessing Huntington disease onset and severity Brain Communications
Inconsistent attentional contexts impair relearning following gradual visuomotor adaptation J Neurophysiol
Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities The Lancet

Vision: Molecules, Behaviour, Society Research Excellence Cluster

Eye Care Centre (VGH) 2550 Willow Street
Vancouver, BC Canada V5Z 3N9
Website vision.ubc.ca

Research Excellence Clusters at UBC Vancouver is a joint initiative of the Provost and Vice-President, Academic, UBC Vancouver and the Vice-President, Research and Innovation. Funding support for the clusters is provided by Academic Excellence Funds – UBC Vancouver.

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