Molecular, Cellular and Eye

Theme 1

Discoveries in the molecular, proteomic and cellular make-up of eye tissues.

The retina is an extension of the central nervous system; photoreceptors are post-mitotic and their loss leads to irreversible blindness. The cornea, the transparent covering of the eye, when diseased limits the light that falls on the retina, leading to vision impairment. Our cluster members have expertise in the retina and cornea. We will use proteomics and super-resolution microscopy to obtain subcellular resolution of the retinal and corneal tissues and identify target proteins that are responsible for retinal and corneal cell atrophy.

Chair

Orson Moritz

Principal Investigators Principal Investigators

Dougls Altshuler, Leonard Foster, Cheryl Gregory-Evans, Blair Leavitt, Zaid Mammo, Joanne Matsubara, Orson Moritz, Ivan Robert Nabi, Claire Sheldon, Elizabeth Simpson

Publications and Articles
Publication Journal or Publisher Publication Date
Mapping protein states and interactions across the tree of life with co-fractionation mass spectrometry Nat Commun
The Effect of Nutrient Deprivation on Early Life Small Intestinal Mucosal Microbiome and Host Proteome J Nutr
Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study Lancet Neurol.
Investigating trade-offs between ovary activation and immune protein expression in bumble bee (Bombus impatiens) workers and queens Proc. R. Soc. B.
Metagenomic analysis of the honey bee queen microbiome reveals low bacterial diversity and Caudoviricetes phages mSystems
Hummingbirds use distinct control strategies for forward and hovering flight Proc. R. Soc. B.
Membrane contact site detection (MCS-DETECT) reveals dual control of rough mitochondria–ER contacts J Cell Biol
Caveolin-1 promotes mitochondrial health and limits mitochondrial ROS through ROCK/AMPK regulation of basal mitophagic flux The FASEB Journal
Tominersen in Adults with Manifest Huntington’s Disease New Eng. J. Med
Deep Learning-Enabled MS/MS Spectrum Prediction Facilitates Automated Identification Of Novel Psychoactive Substances Anal. Chem.

Vision: Molecules, Behaviour, Society Research Excellence Cluster

Eye Care Centre (VGH) 2550 Willow Street
Vancouver, BC Canada V5Z 3N9
Website vision.ubc.ca

Research Excellence Clusters at UBC Vancouver is a joint initiative of the Provost and Vice-President, Academic, UBC Vancouver and the Vice-President, Research and Innovation. Funding support for the clusters is provided by Academic Excellence Funds – UBC Vancouver.

UBC Crest The official logo of the University of British Columbia. Urgent Message An exclamation mark in a speech bubble. Caret An arrowhead indicating direction. Arrow An arrow indicating direction. Arrow in Circle An arrow indicating direction. Arrow in Circle An arrow indicating direction. Chats Two speech clouds. Facebook The logo for the Facebook social media service. Information The letter 'i' in a circle. Instagram The logo for the Instagram social media service. External Link An arrow entering a square. Linkedin The logo for the LinkedIn social media service. Location Pin A map location pin. Mail An envelope. Menu Three horizontal lines indicating a menu. Minus A minus sign. Telephone An antique telephone. Plus A plus symbol indicating more or the ability to add. Search A magnifying glass. Twitter The logo for the Twitter social media service. Youtube The logo for the YouTube video sharing service.