Molecular, Cellular and Eye

Theme 1

Discoveries in the molecular, proteomic and cellular make-up of eye tissues.

The retina is an extension of the central nervous system; photoreceptors are post-mitotic and their loss leads to irreversible blindness. The cornea, the transparent covering of the eye, when diseased limits the light that falls on the retina, leading to vision impairment. Our cluster members have expertise in the retina and cornea. We will use proteomics and super-resolution microscopy to obtain subcellular resolution of the retinal and corneal tissues and identify target proteins that are responsible for retinal and corneal cell atrophy.

Chair

Orson Moritz

Principal Investigators Principal Investigators

Dougls Altshuler, Leonard Foster, Cheryl Gregory-Evans, Blair Leavitt, Zaid Mammo, Joanne Matsubara, Orson Moritz, Ivan Robert Nabi, Claire Sheldon, Elizabeth Simpson

Publications and Articles
Publication Journal or Publisher Publication Date
Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration Brain
Cleavage of 14-3-3ε by the enteroviral 3C protease dampens RIG-I-mediated antiviral signaling J Virol
From the eye to the wing: neural circuits for transforming optic flow into motor output in avian flight J Comp Physiol A Neuroethol Sens Neural Behav Physiol
Ligand-independent activation of platelet-derived growth factor receptor β promotes vitreous-induced contraction of retinal pigment epithelial cells BMC Ophthalmology
Truncated TDP-43 proteoforms diagnostic of frontotemporal dementia with TDP-43 pathology Alzheimer's & Dementia
Discovering Protein-Protein Interactions using Co-Fractionation-Mass Spectrometry with Label-Free Quantitation Methods in Molecular Biology
Purinergic signaling via P2X receptors and mechanisms of unregulated ATP release in the outer retina and age-related macular degeneration Frontiers in Neuroscience
Progranulin is an FMRP target that influences macroorchidism but not behaviour in a mouse model of Fragile X Syndrome Current Research in Neurobiology
FTD-associated behavioural and transcriptomic abnormalities in 'humanized' progranulin-deficient mice: A novel model for progranulin-associated FTD Neurobiology of Disease
DataCurator.jl: efficient, portable and reproducible validation, curation and transformation of large heterogeneous datasets using human-readable recipes compiled into machine-verifiable templates Bioinformatics Advances

Vision: Molecules, Behaviour, Society Research Excellence Cluster

Eye Care Centre (VGH) 2550 Willow Street
Vancouver, BC Canada V5Z 3N9
Website vision.ubc.ca

Research Excellence Clusters at UBC Vancouver is a joint initiative of the Provost and Vice-President, Academic, UBC Vancouver and the Vice-President, Research and Innovation. Funding support for the clusters is provided by Academic Excellence Funds – UBC Vancouver.

UBC Crest The official logo of the University of British Columbia. Urgent Message An exclamation mark in a speech bubble. Caret An arrowhead indicating direction. Arrow An arrow indicating direction. Arrow in Circle An arrow indicating direction. Arrow in Circle An arrow indicating direction. Chats Two speech clouds. Facebook The logo for the Facebook social media service. Information The letter 'i' in a circle. Instagram The logo for the Instagram social media service. External Link An arrow entering a square. Linkedin The logo for the LinkedIn social media service. Location Pin A map location pin. Mail An envelope. Menu Three horizontal lines indicating a menu. Minus A minus sign. Telephone An antique telephone. Plus A plus symbol indicating more or the ability to add. Search A magnifying glass. Twitter The logo for the Twitter social media service. Youtube The logo for the YouTube video sharing service.