Ophthalmic Imaging for Eye and Brain Disease

Theme 4

Development of cutting-edge imaging devices to diagnose eye diseases and identify ocular biomarkers to diagnose brain diseases.

Ophthalmic imaging of the retina is in its “golden era”. Retinal tissues have a myriad of textural/contrast features that can be visualized and captured under different lighting and contrast settings. Today, in vivo imaging of the retina in animal models can identify dying retinal ganglion cells in glaucoma or in Alzheimer’s. Engineering and animal model experts will work side- by-side to identify relevant textural and contrast signatures that represent eye and/or brain diseases.

Chair

Myeong Jin Ju

Principal Investigators

Lauren Ayton, Hye Jin Chung, Cheryl Gregory-Evans, Myeong Jin Ju, Geoffrey Law, Blair Leavitt, Da Ma, Zaid Mammo, Joanne Matsubara, Orson Moritz, Ipek Oruç, Jacqueline Quandt, Shuo Tang

Publications and Articles
Publication Journal or Publisher Publication Date
Label-free multimodal imaging with simultaneous two-photon and three-photon microscopy and kernel-based nonlinear scaling denoising Biomed. Opt. Express
Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study Lancet Neurol.
Predicting Four-Year’s Alzheimer’s Disease Onset Using Longitudinal Neurocognitive Tests and MRI Data Using Explainable Deep Convolutional Neural Networks J. Alzheimer's Dis
Tominersen in Adults with Manifest Huntington’s Disease New Eng. J. Med
Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation JBC
Polarization-Diversity Optical Coherence Tomography Assessment of Choroidal Nevi Invest Ophthalmol Vis Sci
Perspectives of carriers of X-linked retinal diseases on genetic testing and gene therapy: A global survey Clin Genet
Multimodal imaging and PD-OCT analysis of an isolated focal scleral nodule in a young female Can J Ophthalmol
FTD-associated behavioural and transcriptomic abnormalities in 'humanized' progranulin-deficient mice: A novel model for progranulin-associated FTD Neurobiology of Disease
DataCurator.jl: efficient, portable and reproducible validation, curation and transformation of large heterogeneous datasets using human-readable recipes compiled into machine-verifiable templates Bioinformatics Advances

Vision: Molecules, Behaviour, Society Research Excellence Cluster

Eye Care Centre (VGH) 2550 Willow Street
Vancouver, BC Canada V5Z 3N9
Website vision.ubc.ca

Research Excellence Clusters at UBC Vancouver is a joint initiative of the Provost and Vice-President, Academic, UBC Vancouver and the Vice-President, Research and Innovation. Funding support for the clusters is provided by Academic Excellence Funds – UBC Vancouver.

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