Basic Mechanisms of Vision

Theme 1

Discoveries in the molecular, proteomic and cellular make-up of eye tissues.

The retina is an extension of the central nervous system; photoreceptors are post-mitotic and their loss leads to irreversible blindness. The cornea, the transparent covering of the eye, when diseased limits the light that falls on the retina, leading to vision impairment. Our cluster members have expertise in the retina and cornea. We will use proteomics and super-resolution microscopy to obtain subcellular resolution of the retinal and corneal tissues and identify target proteins that are responsible for retinal and corneal cell atrophy.

Chair

Orson Moritz

Principal Investigators Principal Investigators

Dougls Altshuler, Leonard Foster, Cheryl Gregory-Evans, Blair Leavitt, Zaid Mammo, Joanne Matsubara, Orson Moritz, Ivan Robert Nabi, Claire Sheldon, Elizabeth Simpson

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Publications and Articles
Publication Journal or Publisher Publication Date
Spatially selective multiphoton photothermolysis guided by reflectance confocal microscopy for precise vessel closure in the mouse eye limbus Biomedical Optics Express
Granzyme B from mast cells contributes to choroidal neovascularization in a model of wet age-related macular degeneration Frontiers in Immunology
Potential roles of extracellular granzyme B in corneal and conjunctival diseases: A narrative review Experimental Eye Research
Accuracy of intraocular lens power calculations in patients undergoing combined cataract surgery with Descemet stripping only: a pilot study bioRxiv preprint
Prominin-1-null Xenopus laevis develop subretinal drusenoid-like deposits, cone-rod dystrophy and RPE atrophy
In vivo multi-contrast depth-resolved choroidal imaging of a mouse using polarization-diversity optical coherence tomography Optics Letters
Exploring the role of granzyme B in subretinal fibrosis of age-related macular degeneration Frontiers in Immunology
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization Angiogenesis
The Effect of Nutrient Deprivation on Early Life Small Intestinal Mucosal Microbiome and Host Proteome J Nutr
Safety and efficacy of laquinimod for Huntington's disease (LEGATO-HD): a multicentre, randomised, double-blind, placebo-controlled, phase 2 study Lancet Neurol.
Vision: Molecules, Behaviour, Society signature

Vision: Molecules, Behaviour, Society Research Excellence Cluster

Eye Care Centre (VGH) 2550 Willow Street
Vancouver, BC Canada V5Z 3N9
Website vision.ubc.ca

Research Excellence Clusters at UBC Vancouver are funded through the Grants for Catalyzing Research Clusters program.

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