Ben Cardoen

PhD Student

Affiliate Trainee

Computing Science

Faculty of Applied Sciences

Simon Fraser University

Mr. Cardoen received his Bachelor of Science degree in computing science at the University of Antwerp in Belgium in 2015. In 2017, Mr. Cardoen received his Masters of Science degree in computer science at the University of Antwerp in Belgium. Mr. Cardoen's areas of expertise are Intelligent methods for sub-precision / multichannel interaction analysis and reconstruction in superresolution microscopy.

Mr Cardoen's current focus is on the reproducible, accurate quantification of ER-mitochondria contacts (10-80nm) below the precision of the acquisition (~100nm) in multichannel (2+) 3D STED microscopy, and protein structure interaction (5nm) in single molecule localization microscopy (~20nm). Quantifying these interactions in fluorescence based microscopy enables the identification of novel mechanisms and with it the quantification of dysfunctional interactions, which in human populations are strongly associated with neurodegenerative disease, metabolic disorders, and cancer. To further these aims, Mr. Cardoen develops intelligent methods that reconstruct the actual interaction using vector field learning, belief theory, and adaptive/self-tuning signal processing. As the computational part of their strong interdisciplinary team (UBC, Life Sciences Institute / Medical Image Analysis Research Group, SFU) their novel methods have been published or are under review in Q1 venues such as IEEE Transactions in Medical Imaging, Cellular and Molecular Life Sciences, and the Journal of Cell Biology, among others. All methods are published under an open source license, with container versions available for maximal reproducibility.

If Mr. Cardoen could collaborate with other types of researchers, he would collaborate with clinician researchers, bioengineers, who require novel robust reproducible computational methods to quantify multichannel interaction analysis in superresolution microscopy beyond the resolution of the acquisition, to accelerate scientific discovery.

Mr. Cardoen enjoys hiking, mountain biking, and philosophy.

Research Keywords
  • single molecule localization microscopy, superresolution microscopy, mitochondria, caveolae, discrete event simulation, hyperheuristics, belief theory, vectorfield learning, parallelization, reproducibility

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